Special Feature: Continuous Processing, Microreactors and Flow Chemistry

Flash Chemistry: Fast Chemical Synthesis in Flow Microreactors

The length of time that the solution remains inside the reactor channels—the residence time—can be greatly reduced by adjusting the length of the channels in flow microreactors. This feature is extremely useful in controlling reactive species. Unstable short-lived reactive species can be generated and transferred to another location to be used in the next reaction before they decompose. Therefo...

Continuous flow processing from microreactors to mesoscale: the Bohlmann-Rahtz cyclodehydration reaction.

The cyclodehydration of a number of Bohlmann-Rahtz aminodienones exemplifies the use of continuous flow processing to transfer operations from commercial microreactors and microwave batch reactors to mesoscale production using different technology platforms, including a microwave flow reactor.

Single-molecule chemistry and biology special feature: introduction to the special feature on single-molecule chemistry and biology.

T he advent of experiments in single-molecule chemistry 20 years ago (1, 2) generated a new type of molecular spectroscopy and provided new ways of looking at the dynamics and reactions of biomolecules. In ordinary ensemble experiments, one measures the average over a large number of molecules, so that individual differences between molecules are unobservable. Early spectroscopic studies of sin...

Enantioselective Organocatalysis in Microreactors: Continuous Flow Synthesis of a (S)-Pregabalin Precursor and (S)-Warfarin

Continuous flow processes have recently emerged as a powerful technology for performing chemical transformations since they ensure some advantages over traditional batch procedures. In this work, the use of commercially available and affordable PEEK (Polyetheretherketone) and PTFE (Polytetrafluoroethylene) HPLC (High Performance Liquid Chromatography) tubing as microreactors was exploited to pe...

Furrow geometry nnder surge and continuous flow